Erina Vlashi është një ato të reja shqiptare që shkoi në Amerikë për të vazhduar studimet dhe prej arritjeve të shkëlqyera sot është asistente Profesore në Universitetin e Kalifornisë në Los Angelos, një nga më prestigjiozet të SHBA në kërkimet shkencore për shërimin e kancerit.
Erina Vlashi, kjo shkencëtare shqiptaro-amerikane është një krenari kombëtare sepse të gjitha arritjet e saj i dedikohen punës të saj këmbëngulëse.
Unë Erinën e njoh që kur ishte e vogël. Kemi banuar në të njëjtin pallat në Tiranë. Ishim si një familje e madhe. Erina sapo mbaroi gjimnazin Ismail Qemali me rezultate të shkëlqyera shkoi në SHBA në një familje Amerikane për të vijuar shkollimin universitar dhe sot ajo është një shkencëtare me emër, që këtë vit u nderua me çmimin prestigjioz nga Shoqata Amerikane e Radioterapise Onkologjike (ASTRO).
Lexuesit të respektuar po i sjell këtu njoftimin që jep shtypi amerikan në shkrimin e titulluar: “Shkencëtarja në Universitetin e Kalifornisë në Los Anxheles merr çmim prestigjoz”.
Artikulli më poshtë vijon:
“Një shkencëtare në Qendrën e Kancerit te Universiteti i Kalifornias në Los Angeles (UCLA) ka marrë një çmim prestigjoz nga Shoqata Amerikane e Radioterapisë Onkologjike (ASTRO) prej 100,000 dollarë në vit për dy vjet rresht.
Ky çmim jepet një herë në vit, vetëm nje profesori në Amerikë që është në fillimet e karrierës për kërkime shkencore për kancerin. Këto fonde kanë për qëllim të mbështesin kërkimet shkencore që përqëndrohen te radioterapia për kancerin, biologjia dhe fizika e radioterapisë së kancerit.
Profesoresha Erina Vlashi, profesoreshë asistente, në Departamentin e Radioterapisë Onkologjike në Shkollën e Mjeksisë David Geffen në UCLA do t’i përdori fondet e çmimit për të thelluar kërkimet rreth ndryshimeve që radioterapia shkakton në metabolizmin e qelizave të kancerit që mund të rezultojnë në reziztencë ndaj kësaj terapie që përdoret për të trajtuar rreth 70% të pacientëve me kancer. Këto kërkime do të hedhin dritë mbi mënyrën se si qelizat kanceroze riprogramojnë metabolizmin e tyre jo vetëm për të plotësuar kërkesat e larta metabolike qe ushqejne shumfishimin e shpejtë dhe të vazhdueshëm të tyre por edhe për të riprogramuar funksionin e tyre që mund të rezultojë në rezistencë kundër radioterapisë.
Jonsson Comprehensive Cancer Center (JCCC) në UCLA ka rreth 500 shkencëtarë dhe doktorë që janë të angazhuar në kërkime rreth kancerit, parandalimin, diagnostikimin, terapinë dhe kurimin.
JCCC është një nga qendrat e kancerit më të mëdha në Amerikë dhe i është dedikuar promovimit të kërkimeve shkencore dhe aplikimit të zbulimeve që rezultojnë nga këto kërkime në klinikat onkologjike me qëllimin për t’ju ofruar pacientëve të kancerit terapitë më të reja dhe më efektive.”
Këtë çmim prestigjioz e merr pikërisht shkencëtarja e re shqiptaro-amerikane Erina Vlashi e cila e ka fituar këtë çmim me punën e saj brilante në kërkimin shkencor për kurimin e kancerit.
Erina Vlashi sot jeton si shtetase Amerikane me familjen e saj në Kaliforni, ku ajo gëzon respektin dhe besimin e merituar nga stafi shkencor që e vlerësoi Erina Vlashin me çmimin prestigjioz.
Natyrisht Erina Vlashi ka provuar dhe vërtetuar se besimin e treguar ndaj saj, ajo e shpërblen me arritje të shkëlqyera si kontribut për ta mundur sëmundjen e shekullit.
Erina Vlashit i urojmë sukseset më të larta sepse arritjet e saj i takojnë gjithë shqiptarëve. / Elida Buçpapaj
* Më poshtë keni CV e Erina Vlashit ku shihen qartë se suksesi nuk është një fjalë goje, por pasojë e një pune të madhe.
CURRICULUM VITAE
Erina Vlashi, Ph.D.
Date of Birth: December 17, 1977
Place of Birth: Durrës, Albania
Citizenship: American
Title: Assistant Professor
Division of Molecular and Cellular Oncology
Department of Radiation Oncology
David Geffen School of Medicine at UCLA
University of California, Los Angeles
Business address: Department of Radiation Oncology
David Geffen School of Medicine at UCLA
10833 Le Conte Ave
Los Angeles, CA 90095-1714
B3-109 CHS
Office: 310-825-3064
Cell: 310-923-5696
EDUCATION & DEGREES
1984 – 1995 Primary school, and high school, Tirana, Albania
1995 – 1996 Senior year of high school, Livonia, Michigan, USA
1996 – 2000 Bachelor of Arts (Major: Chemistry) Hillsdale College, Hillsdale, MI
2000 – 2007 Ph.D. Thesis “Real time, non-invasive, in vivo imaging of targeted drugs to solid tumors via a high affinity ligand: Implications to improving targeted-drug delivery”, Prof. Philip S. Low, Ralph C. Corley Distinguished Professor of Chemistry, Purdue University, Department of Chemistry, West Lafayette, IN, USA
2007-2010 Postdoctoral-scholar, Department of Radiation Oncology, Roy E. Coats Research Laboratories, UCLA School of Medicine
Supervisor: Frank Pajonk, M.D. Ph.D.
PROFESSIONAL EXPERIENCE
Present Position:
August 2012-present Assistant Professor, Department of Radiation Oncology, David Geffen School of Medicine at UCLA, Los Angeles, CA
MEMBERSHIPS IN PROFESSIONAL SOCIETIES:
1997-2005 Iota Sigma Pi Chemical Honor Society
2004-2007 National American Chemical Society (ACS)
2008-present American Association for Cancer Research (AACR)
2007-present Radiation Research Society (RRS)
2016-present American Society for Therapeutic Radiology and Oncology (ASTRO)
2016-present European Society for Radiotherapy and Oncology (ESTRO)
FORMAL TEACHING 2000-2002 (Purdue University)
Graduate teaching assistant courses (General Chemistry)
FORMAL TEACHING 2008-present (UCLA)
Radiation Oncology Clinical Didactic Lecture Series (ROCDLS): Cancer Biology Course
October 18, 2013: Tumor Control Probability
November 8, 2013: Normal Tissue Responses to Radiotherapy
November 15, 2013: Interactions of Radiotherapy with Other Agents
May 20, 2016: Tumor Control Probability
June 24, 2016: Normal Tissue Responses to Radiotherapy
March 24, 2017: Tumor Control Probability
Radiation Oncology Clinical Didactic Lecture Series (ROCDLS): Academic Development and Research for Junior Investigators
June 27, 2016: Women in Science and Academia
The 2017 UCLA Department of Radiation Oncology – Radiobiology Course (open to everyone)
May 5, 2017: Stem cells in normal and cancerous tissues
Science Graduate and Undergraduate Courses
UCLA Physics in Biology and Medicine (PBM) Graduate Program:
Spring 2008: PBM 260A Seminar Series – Cancer Stem Cells – Do they matter?
(1hour lecture, 10 students, lecture open to public)
Spring 2009: PBM 260A Seminar Series – Cancer stem cell imaging – detecting the seed of evil
(1 hour lecture, 10 students, lecture open to public)
Spring 2013: PBM 204 – Cancer stem cells and radiation
(2 hour lecture, 11 students)
Spring 2013: PBM 223 – Seminars in Radiation Biology (2 hour discussion, 3 students)
Spring 2014: PBM 204 – Cancer stem cells and radiation
(2 hour lecture, 11 students)
Spring 2014: PBM 223 – Seminars in Radiation Biology – Angiogenesis in cancer
(2 hour discussion, 4 students)
Fall 2014: PBM 260A Seminar Series – Radiation-induced reprogramming in cancer
(1 hour lecture, 8 students, lecture open to public)
Spring 2016: PBM204 – Tumor Responses to Radiation therapy
(2 hour lecture, 11 students)
Spring 2016: PBM 204 – Cancer stem cells and irradiation
(2 hour lecture, 11 students)
Winter 2017: 260B Seminar Series – Cancer Stem Cells and Cancer Cell Plasticity, a game of Catch-22
(2 hour lecture, 12 students, lecture open to public)
Winter 2017: PBM204 – Tumor Responses to Radiation therapy
(2 hour lecture, 8 students)
Winter 2017: PBM204 – Cancer stem cells and radiation
(2 hour lecture, 8 students)
C234 – Ethics and Accountability in Biomedical Research:
Spring 2016: C234 – Ethics and Accountability in Biomedical Research
(2 hour discussion of case studies, 12 students)
Spring 2017: C234 – Ethics and Accountability in Biomedical Research
(2 hour discussion of case studies, 11 students)
Mentoring:
Former mentoring:
High School Student Supervision
Milana Bochur Dravter – Milken Community Schools, Los Angeles (2012-2014)
competed for Intel Science Talent Search, the nation’s most prestigious pre-college science competition. It honors exceptional high school seniors (~1,800 applicants) for their scientific research and their potential as future leaders in the scientific community. Milana qualified for the Semifinals.
Daniela Tour — Milken Community Schools, Los Angeles (2015-2016)
High School Student Supervision
James Durgin – AMGEN Scholar Summer Student (2007)
Current position: Medical Physicist at Center for Neurosciences, Tucson, Arizona
Steven He – AMGEN Scholar Summer Student (2008)
Nandini Mohan – UCLA undergraduate student (2008)
Polin Nikolay – UCLA undergraduate student (2008-2009)
Joseph Behjat – UCLA undergraduate student (2010-2011)
Maha Kazmi – UCLA undergraduate student (2013-2014)
Alex Nourian – UCLA pre-med undergraduate student (2013-2014)
Current position: Medical student at David Geffen School of Medicine UCLA
Xiancheng Wu – UCLA undergraduate student (2014)
Aly McDonald – UCLA undergraduate student (2013-2014)
Current position: Drug Substance MSAT Intern at Genentech, San Francisco
Andrea Nguyen – UCLA pre-med undergraduate student (2014-2016)
Current position: Medical student at St. George’s University
Philip Brower – UCLA undergraduate student (2014-2015)
Dionatan Sueda – visiting undergraduate student (summer 2015)
Daniel Afar – UCLA pre-med undergraduate student (summer 2015)
Milana Bochur Dravter – visiting undergraduate student from Yale University (summer 2015)
Current position: undergraduate at Yale University
Garret Yu – UCLA pre-med undergraduate student (2013-2016)
Current position: Medical School
Ryan Tsuyoshi Siu – UCLA undergraduate student (2014-2016)
Shauna McLaughlin — UCLA pre-Med undergraduate student (9/2015-2016)
Kevin Dong — 2016-2017
Current position: Senior Research Associate, UCSD
Preksha Dheri – Stony Brook University (New York) undergraduate, summer 2017
Current position: undergraduate at Stony Brook University
Medical Student Supervision
Ayse Betul Topak – visiting medical student from Turkey (2008)
Malcom Mattes – Medical student at David Geffen School of Medicine at UCLA (2008)
Current position: Radiation Oncologist Assistant Professor, West Virginia University
Patrick Evers – Medical student at David Geffen School of Medicine at UCLA (2009-2010)
Current position: Clinical Cardiology Fellow, Heart Institute, Cincinnati Children’s Hospital Medical Center
Graduate Student Supervision
Hemal Semwal — rotation graduate student from the BMP graduate program at UCLA (2014)
Le Zhang — Shanghai Jiaotong University School Of Medicine in P. R. China (9/2015-10/2016)
Current position: Oncology Residency Training, Shanghai East Hospital, Tongji University
Yazeed Alhiyari — graduate student from the BMP graduate program at UCLA (2012-2014)
Current position: Lecturer, California State University, Northridge
Raquel Hernandez-Solis – rotation graduate student (2016)
Current position: Graduate student at UCLA, Cell and Developmental Biology Graduate Program
PhD Defense Committees
Yazeed Alhiyari – BMP Graduate Program at UCLA (December 8, 2014)
Tom Thomas – Biomedical Science and Translational Medicine Program at Cedars-Sinai Medical Center (July 24, 2017)
Current mentoring:
High School Student Supervision
Michael Bochkur Dratver — Milken Community Schools, Los Angeles (2016-present)
Brittney Moalemzadeh — Milken Community Schools, Los Angeles (2017-present)
Undergraduate Supervision
Lila Vasquez — UCLA Biology Pre-Med undergraduate student (5/2016-present)
Sydney Dong — UCLA pre-Med undergraduate student, 2017-present
Anahita Sehgal — UCLA pre-Med undergraduate student, 2017-present
Graduate Student Supervision
None
Postdoctoral Supervision, Current
Kruttika Bhat, 2015-present; Sara Duhachek Muggy, 2015-present
AD HOC JOURNAL REVIEWER ACTIVITIES:
OncoTargets and Therapy: April 2017, May 2017
Molecules: Jan 2017
Cancer Management and Research: Nov 2016
Anti-Cancer Agents in Medicinal Chemistry: May 2016
Journal of Otolaryngology and Rhinology: April 2016
Radiation Research: March 2016
Head and Neck: Feb 2016, May 2016
International Journal of Molecular Sciences: Dec 2015
Journal of Cellular and Molecular Medicine: Aug 2015
Expert Opinion On Therapeutic Targets: June 2015
Radiation Oncology: March 2015
Clinical Cancer Research: Jan 2014
Oncogene: Jan 2014
Molecular Cancer: Dec 2013
Molecules: Nov 2013
Neoplasia: Sept 2013, Oct 2013
BMC Cancer: June 2010, Sept 2012 (x2), Jan, April, May, Oct. 2013, Jan 2015
Journal of Neuro-Oncology: June 2010, May, Aug (x2), Nov, Dec 2013, Dec 2015, May 2017
International Journal of Hyperthermia: Sept 2012
International Journal of Radiation Oncology, Biology, and Physics: July 2010
HONORS AND SPECIAL AWARDS
2017 Early Career Investigator (ECI) travel award, Radiation Research Society
2016 Early Career Investigator (ECI) travel award, Radiation Research Society
2010 Scholar-In-Training Award, Radiation Research Society (unable to accept due to not being able to attend the conference)
2010 AACR-Bristol-Myers Squibb Oncology Scholar-in-Training Award
2008 Marie Curie Award, Radiation Research Society
2008 Scholar-In-Training Award, Radiation Research Society
2008 AACR-AFLAC Scholar-In-Training Award
2006 Sigma Xi Graduate Student Research Awards Competition, 1st Place
2005 Women in Science Travel Grant Award
REVIEWER FOR STUDY SECTIONS
December 2014 – Department of Defense, U.S. Army Medical Research and Materiel Command, Congressionally Directed Medical Research Programs (CDMRP) – fiscal year 2014 Peer Reviewed Medical Research Program (PRMRP)
December 2016 – Italian Scientists and Scholars in North America Foundation (ISSNAF), Italian National Institute of Cancer (INT) – internal oncology grants
PROFESSIONAL DEVELOPMENT
2009: Pathobiology of Cancer Workshop*, July 2009, Snowmass, CO (*competitive participant selection)
2016: Integrating Biology and Physics in Radiation Oncology* (IBPRO) workshop, May 2016, Detroit, MI (*competitive participant selection)
RESEARCH GRANTS
ACTIVE
U19AI067769-11 (McBride/Weidhaas/Chute) 8/11/2015-07/31/2020 4.08 calendar
NIH/NIAID $2,024,978
The UCLA Center for Medical Countermeasures Against Radiation
This is the third renewal application for the UCLA-CMCR Program. The aims are to discover novel agents that can be used to mitigate the effects of radiation exposure such as might occur if nuclear materials were to be used for terrorist purposes. We have already discovered about 30 such agents and here we propose to optimize and prioritize these and explore how best to use them to counter the multiple possible effects of radiation exposure. I am Co-PI on Project 4 entitled “Radiation mitigation and normal tissue stem cells.”
Role: Co-Investigator
1R01CA2000234 (Pajonk) 08/03/2016-07/31/2021 2.80 calendar
NIH/NCI $240,772
Glioblastoma, Glioblastoma Stem Cells and Radiotherapy
This project studies glioblastoma cell plasticity induced by radiotherapy that leads to resistance and explores ways to inhibit this process by gaining insight into the mechanism.
Role: Co-Investigator
ASTRO JFA (Vlashi) 07/01/2017 – 06/30/2019 4.80 calendar
$100,000 (total directs)
Metabolic reprogramming mediates radiation-induced dedifferentiation of breast cancer cells into cancer stem cells
The long term goal of this project is to understand how early IR-induced changes in the metabolic state of surviving BC cells determine their response to subsequent exposure to IR.
Role: Principal Investigator
PENDING:
R01 (Vlashi) 7/1/2017 – 6/30/2022 3.0 calendar
NIH 250,000 (total directs)
Metabolic reprogramming of radiation-induced of breast cancer initiating cells
This proposal explores the role of glycolytic metabolism, specifically the role of rate-limiting
glycolytic enzymes PFK1 and PKM2, in the radiation-induced reprogramming of BC cells, with the goal of preventing radiation-induced reprogramming from occurring and improving the efficacy of radiation therapy in breast cancer.
Role: Principal Investigator
RESEARCH COMPLETED:
1R01CA161294 (Pajonk) 07/09/2012-04/30/2017 3.72 calendar
NIH/NCI $201,275
Erythropoietin and Breast Cancer Stem Cells
This project studies the interplay between erythropoietin and radiation in cancer stem cells.
ROSG2014-4 Seed Grant (Vlashi, PI) 07/01/2014-06/30/2016 0.6 calendar
Department of Radiation Oncology, UCLA $30,000
Inhibiting radiation-induced reprogramming of glioblastoma multiforme stem cell
This project will investigate radiation-induced reprogramming of GBM cells, and perform high throughput screening for compounds that prevent this phenomenon.
W81XWH-11-1-0531 (Formenti/Demaria/McBride) 11/01/2011-10/30/2015 6.52 calendar
US Army/MRAA $371,252
Joint Breast Cancer Team Award
Radiation-Induced Vaccination to Breast Cancer
To determine if treatment with anti- TGFβ antibody (Fresolimumab) and localized radiation therapy (RT) achieves an abscopal tumor regression and whether it correlates with immunological changes in patients with metastatic breast cancer, and to investigate the mechanisms of synergy between radiation and TGFβ blockade in pre-clinical models of metastatic breast cancer.
UCLA CTSI Award/Grant No.: UL1TR000124 (Vlashi, PI) 11/31/2013-07/31/2013
UCLA CTSI Core Voucher Award $10,000 (total)
NIBIB Training Grant (Kirschstein – NRSA) 04/27/2007-04/27/2010
Cancer stem cells in glioma
This project investigated the use of low proteasome activity of cancer stem cells for their identification, tracking and therapy.
National Institute of Biomedical Imaging & Bioengineering5 T32 EB002101-30
Principal Investigator: Michael McNitt-Gray, Ph.D.
Role: Post-doctoral scholar
INVITED PRESENTATIONS
October 2017: “Cancer stem cells” Radiation Research Society, 63nd Annual Meeting, Topical Review Speaker, Cancun, Mexico.
June 9-10, 2017: “Radiotherapy and glioma stem cells” UCLA Radiation Oncology Workshop: Integration of State-of-the-Art Innovations into Clinical Radiation Oncology Practice (CME-accredited)
May 5-6, 2017: “Stem cells in normal and cancerous tissue” UCLA Department of Radiation Oncology – Radiobiology Course
March 2017: “Treatment-induced metabolic plasticity leads to cancer cell reprogramming” UCLA Jonsson Comprehensive Cancer Center Research Seminar Series, UCLA
October 2016: “Radiation, metabolism and reprogramming of cancer stem cells” Radiation Research Society, 62nd Annual Meeting, Cancer Stem Cell Symposium, Hawaii
December 2015: “Inhibition of radiation-induced reprogramming in breast cancer” Department of Radiation Oncology, David Geffen School of Medicine at UCLA, DMCO Seminar Series, Los Angeles
March 2014: “Radiation-induced reprogramming of GBM stem cells” Neural Stem Cell Focus Group, Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research, David Geffen School of Medicine at UCLA, Los Angeles
December 2013: “Cancer Stem Cells, Reprogramming and Metabolics” Department of Radiation Oncology, David Geffen School of Medicine at UCLA, DMCO Lunch Seminar Series, Los Angeles
July 2009: “Differential effects of the proteasome inhibitor NPI-0052 against glioma cells” Department of Radiation Oncology, David Geffen School of Medicine at UCLA, Los Angeles
September 2008*: “Exploiting the low proteasome activity of glioma stem cells for their identification, tracking and elimination” Radiation Research Society Annual Conference, Boston, MA, *Marie Curie Award Presentation
September 2008: “Low proteasome activity of glioma stem cells can be exploited for characterization of radiation and chemotherapy resistance” Radiation Research Society, Cancer Stem Cells Joint RRS/ASTRO Minisymposium, Session Chair, Boston, MA
April 2008: “Prospective identification, tracking, and targeting of cancer-initiating cells in breast cancer and glioma via low proteasome activity” 99th Annual Meeting of American Association of Cancer Research, Generation and Maintenance of Cancer Stem Cells Minisymposium, San Diego, CA
March 2007: “Real time, non-invasive, in vivo imaging of targeted drugs to solid tumors via a high affinity ligand: Implications to improving targeted-drug delivery”, Endocyte Inc., West Lafayette, IN
December 2005: “Pharmacokinetics of folate-conjugated drugs into solid tumor tissue” Women in Science Program, Purdue University, West Lafayette, IN
August 2005: “Time-dependent accumulation of small molecular weight folate-conjugates into solid tumor tissue, in real time”, Endocyte Inc., West Lafayette, IN
February 2004: “The dynamics of penetration of folate conjugates into solid tumor tissue” Endocyte Inc., West Lafayette, IN
PUBLICATIONS/BIBLIOGRAPHY
RESEARCH PAPERS
A. RESEARCH PAPERS – PEER REVIEWED
Duhacheck-Muggy S, Bhat K, Vlashi E, Pajonk F. Growth differentiation factor 11 does not mitigate the lethal effects of total abdominal irradiation. Radiation Research. 2017 Aug 22.
PMID: 28829672
Zhang L, Xu L, Zhang F, Vlashi E. Doxycycline inhibits the cancer stem cell phenotype and epithelial-to-mesenchymal transition in breast cancer. Cell Cycle. 2016 Oct. 18
PMID: 27753527
Vlashi E, Chen AM, Boyrie S, Yu G, Nguyen A, Brower PA, Clayton BH, Pajonk, F. Radiation-induced dedifferentiation of head and neck cancer cells into cancer stem cells depends on HPV status. Int J Radiat Oncol Biol Phys. 2016 Apr 1; 94(5):1198-206
PMID: 27026319
Varghese B, Vlashi E, Xia W, Ayala Lopez W, Paulos CM, Reddy J, Xu LC, Low PS. Receptor-B in activated macrophages: ligand binding and receptor recycling kinetics. Mol Pharm. 2014 Oct 6; 11(10): 3609-16
PMID: 25166491
Vlashi E, Lagadec C, Vergnes L, Reue K, Frohnen P, Chan M, Alhiyari Y, Dratver MB, Pajonk F. (2014). Metabolic differences in breast cancer stem cells and differentiated progeny. Breast Cancer Res. Treat. 2014 Aug; 146(3):525-34
PMID: 25007966
Lagadec C, Vlashi E, Bhuta S, Lai C, Mischel P, Werner M, Henke M, Pajonk F. Tumor cells with low proteasome subunit expression predict overall survival in head and neck cancer patients. BMC Cancer. 2014 Mar 5; 14(1): 152
PMID: 24593279
Lagadec C, Vlashi E, Frohnen P, Alhiyari Y, Chann M, Pajonk F. The RNA-binding protein Musashi-1 regulates proteasome subunit expression in breast cancer and glioma CSCs/tumor-initiating cell. Stem Cells. 2014 Jan; 32(1): 135-44
PMID: 24022895
Vlashi E, Kelderhouse LE, Sturgis JE, Low PS. Effect of folate-targeted nanoparticle size on their rates of penetration into solid tumors. ACS Nano. 2013 Oct 22; 7(10): 8573-82
PMID: 24020507
Vlashi E, Lagadec C, Chann M, Frohnen P, McDonald AJ, Pajonk F. Targeted elimination of breast cancer cells with low proteasome activity is sufficient for tumor regression. Breast Cancer Res Treat. 2013 Sep; 141(2): 197-203
PMID: 24013708
Lagadec C, Vlashi E, Alhiyari Y, Phillips TM, Dratver MB, Pajonk F. Radiation-induced Notch signaling in breast cancer stem cells. Int J Radiat Oncol Biol Phys. 2013 Nov 1; 87(3): 609-18
PMID: 23992604
Steinberg M, McBride WH, Vlashi E, Pajonk F. National Institutes of Health funding in radiation oncology: A Snapshot. Int J Radiat Oncol Biol Phys. 2013 Jun 1; 86(2): 234-40
PMID: 23523324
Lagadec C, Vlashi E, Della Donna L, Dekmezian C, Pajonk F. Radiation-induced reprograming of breast cancer cells. Stem Cells. 2012 May; 30(5): 833-44
PMID: 22489015
Vlashi E, Lagadec C, Vergnes L, Matsutani T, Masui K, Poulou M, Popescu R, Della Donna L, Evers P, Dekmezian C, Reue K, Christofk H, Mischel PS, Pajonk F. Metabolic state of glioma stem cells and nontumorigenic cells. Proc Natl Acad Sci. USA. 2011 Sep 20; 108(38): 16062-7
PMID: 21900605
McDonald JT, Kim K, Norris AJ, Vlashi E, Phillips TM, Lagadec C, Della Donna L, Ratikan J, Szelag H, Hlatky L, McBride WH. Ionizing radiation activates the Nrf2 antioxidant response. Cancer Res. 2010 Nov 1; 70(21): 8886-95
PMID: 20940400
Vlashi E, Mattes M, Lagadec C, Della Donna L, Phillips TM, Nikolay P, McBride WH, Pajonk F. Differential effects of the proteasome inhibitor NPI-0052 against glioma cells. Translational Oncol. 2010 Feb; 3(1): 50-5
PMID: 20165695
Lagadec C, Vlashi E, Della Donna L, Pajonk F. Survival, self-renewing capacity and multi-lineage potency of breast cancer initiating cells during fractionated irradiation. Breast Cancer Res. 2010, 12(1): R13
PMID: 20158881
Vlashi E, Sturgis JE, Thomas M, Low PS. Real time, noninvasive imaging and quantitation of the accumulation of ligand-targeted drugs into receptor-expressing solid tumors. Mol Pharm. 2009 Nov-Dec; 6(6): 1868-75
PMID: 19754150
Vlashi E, Kim K, Lagadec C, Della Donna L, McDonald JT, Eghbali M, Sayre J, Stefani E, McBride WH, Pajonk F. In vivo imaging, tracking, and targeting of cancer stem cells. J Natl Cancer Inst. 2009 Mar 4; 101(5): 350-9
PMID: 19244169
Phillips TM, Kim K, Vlashi E, McBride WH, Pajonk F. Effects of recombinant erythropoietin on breast cancer initiating cells. Neoplasia. 2007 Dec; 9(12): 1122-9
PMID: 18084619
Acharya G, Chang C, Doorneweerd DD, Vlashi E, Henne WA, Hartman LC, Low PS, Savran C. Immunomagnetic diffractometry for detection of diagnostic serum markers. J Am Chem Soc. 2007 Dec 26; 129(51): 15824-9
PMID: 18047330
Paulos CP, Varghese B, Widmer R, Breur GJ, Vlashi E, Low PS. Folate-targeted immunotherapy effectively treats established adjuvant and collagen-induced arthritis. Arthritis Res and Ther. 2006, 8(3): R77
PMID:16646988
B. RESEARCH PAPERS – PEER REVIEWED (IN PRESS)
C. RESEARCH PAPERS – PEER REVIEWED (SUBMITTED)
Duhacheck Muggy S, Bhat K, Vlashi E, Pajonk F. Growth differentiation factor 11 does not mitigate the lethal effects of total abdominal irradiation. Radiation Research, May 2017
D. RESEARCH PAPERS – NON-PEER REVIEWED
none
E. RESEARCH PAPERS – NON-PEER REVIEWED (IN PRESS)
None
F. RESEARCH PAPERS – NON-PEER REVIEWED (SUBMITTED)
None
G. RESEARCH PAPERS IN PREPARATION
Bochkur Dratver M, Zhang L, Dong K, Bhat K, Duhacheck Muggy S, Nguyen A, Pajonk F, Vlashi E. Mebendazole potentiates radiation therapy in triple-negative breast cancer.
Zhang L, Dong K, Bhat K, Duhacheck Muggy S, Vlashi E. Radiation-induced phenotype conversion is mediated by PKM2.
Vlashi E, Bhat K, Boyrie S, Duhacheck Muggy S, Bochkur Dratver M, Nathanson D, Yu G, Tsang J, Dong K, McDonald A, Tsuyoshi RS, Damoiseaux R, Kornblum H, Pajonk F. Dopamine receptor antagonists prevent radiation-induced phenotype conversion in glioblastoma.
Vlashi E, Bhat K, Alli C, Chen M, Sandler K, McCloskey S, Pajonk F. Endogenous erythropoietin and breast cancer stem cells.
Vlashi E, Duhacheck Muggy S, Bhat K, Boyrie S, Vasquez LM, Schaue D, Pajonk F. Radiation mitigation of the intestinal acute injury in mice by 1-(4-nirobenzenesulfonyl)-4-penylpiperazine.
CHAPTERS
Yang J, Vlashi E, & Low PS. Folate-linked drugs for the treatment of cancer and inflammatory diseases. Water-soluble Vitamins (book chapter): Subcellular Biochemistry. New York: Springer-Verlag. 2012, 56:163-79
PMID: 22116699
LETTERS TO THE EDITOR
Vlashi E, Pajonk F. Targeted cancer stem cell therapies start with proper identification of the target. Mol Cancer Res. 2010 Feb; 8(2): 291
PMID: 20145040
REVIEWS
Vlashi E, Pajonk P. The metabolic state of cancer stem cells – a valid target for cancer therapy? Free Radic Biol Med. 2015 Feb; 79:264-8.
PMID: 25450330
Vlashi E, Pajonk F. Cancer stem cells, cancer cell plasticity and radiation therapy. Semin Cancer Biol. 2014 Jul 12.
PMID: 25025713
Pajonk F, Vlashi E. Characterization of the Stem Cell Niche and Its Importance in Radiobiological Response. Semin in Radiat Oncol. 2013 Oct; 23(4): 237–241. (Cover page)
PMID: 24012337
Pajonk F, Vlashi E., & McBride WH. Radiation resistance of cancer stem cells – The 4 R’s of Radiobiology Revisited. Stem Cells. 2010 Apr; 28(4): 639-48
PMID: 20135685
Vlashi E, McBride WH, Pajonk F. Radiation responses of cancer stem cells. J. Cell Biochem. 2009 Oct. 1; 108(2): 339-42
PMID: 19623582
ABSTRACTS
Muthukrishnan D, Hinman J, Deb A, Vlashi E, Pajonk F, Sofroniew M, Kornblum H. Radiation induces transdifferentiation of glioblastoma stem cells into endothelial cells. 13th Annual Stem Cell Symposium – Transforming Medicine: Innovation and Discovery at The Broad Stem Cell Research Centers, February 2017, UCLA, Los Angeles
Zhang L, Bhat K, Duhachek Muggy S, Nguyen A, Pajonk F, Vlashi E. Radiation-induced reprogramming of triple negative breast cancer cells is enhanced in cells with low glycolytic flux. Radiation Research Society 62nd Annual Meeting, October 2016, Hawaii. Abstract PS2-18 (Scholar-in-Training Travel award)
Zhang L, Bhat KN, Duhachek Muggy S, Pajonk F, Vlashi E. Metabolic enzymes mediate radiation induced plasticity in cancer stem cells. Radiation Research Society 62nd Annual Meeting, October 2016, Hawaii. Abstract PS2-58 (Early Career Investigator award)
Bhat K, Vlashi E, Boyre S, Duhachek-Muggy S, Zhang L, Pajonk F. Compound IOR#6 prevents radiation-induced phenotype conversion in glioblastoma. Radiation Research Society 62nd Annual Meeting, October 2016, Hawaii. Abstract PS2-32 (Scholar-in-Training Travel award)
Duhachek-Muggy S, Vlashi E, Boyrie S, Bhat K, Pajonk F. Radiation mitigation of the intestinal acute radiation injury in mice by 1-(4-nitrobenzenesulfonyl)-4-penylpiperazine. Radiation Research Society 62nd Annual Meeting, October 2016, Hawaii. Abstract PS7-51
Bochkur Dratver M, Tsuyoshi R, Boyer S, Nguyen A, Pajonk F, Vlashi E. Inhibiting radiation-induced reprogramming of breast cancer cells via metabolic perturbation. Metabolism and Cancer, American Association of Cancer Research (AACR) special conference, June 2015, Bellevue, WA.
T. Siu R*, Frohnen P, Pajonk E, Vlashi E. Elucidating the Mechanism of Radiation-Induced Reprogramming of Cancer Cells. UCLA’s Annual Undergraduate Science Poster Day, UCLA, May 2015 (*Honorary Undergraduate Research Fellow)
Vlashi E, Lagadec C, Chann M, Frohnen P, Hiyari Y, Bochkur Dratver M, Pajonk F. rhEpo synergizes with radiation in enriching the breast cancer stem cell pool explaining inferior treatment outcomes in the clinic. International Wolfsberg Meeting, June 2013, Switzerland.
Lagadec C, Vlashi E, Della Donna L, Dekmezian C, Frohnen P, Chan M, Alhiyari Y, Bochkur Dratver M, Pajonk F. Radiation-induced reprograming of breast cancer cells. International Wolfsberg Meeting, June 2013, Switzerland.
Lagadec C, Vlashi E, Frohnen P, Alhiyari A, Chann M, Pajonk F. The RNA-binding protein Musashi-1 regulates proteasome subunit expression in breast cancer and glioma CSCs/tumor-initiating cells. International Wolfsberg Meeting, June 2013, Switzerland.
Lagadec C, Della Donna L, Vlashi E, Dekmezian C, Pajonk F. Radiation induces Notch-dependent de novo generation of breast cancer stem cells via expression of OCT-4/SOX2/NANOG. Annual Meeting of American Association of Cancer Research – Orlando, March 2011, Abstract 4372
Lagadec C, Vlashi E, Della Donna L, Dekmezian C, Pajonk F. Ionizing Radiation Reprograms Non-Tumorigenic Cancer Cells into Cancer Stem Cells. San Antonio Breast Cancer Symposium – San Antonio, December 2011, Abstract P1-04-06.
Lagadec C, Della Donna L, Vlashi E, Dekmezian C, Pajonk F. Radiation induces Notch-dependent de novo generation of Breast Cancer Stem Cells. San Antonio Breast Cancer Symposium – San Antonio, December 2010, Abstract PD02-10.
Lagadec C, Della Donna L, Vlashi E, Dekmezian C, Pajonk F. CSCs enrichment and CSCs/Progeny phenotype plasticity are driven by Notch signaling pathway in breast cancer cells during radiation treatment. Radiation Research Society Annual Meeting – Maui, September 2010, Abstract PS3.29.
Vlashi E, Lagadec C, Della Donna L, Dekmezian C, Souda P, Whitelegge J, Pajonk F. Regulation of 26S proteasome activity by radiation during the different phases of the cell cycle. Radiation Research Society Annual Meeting- Maui, September 2010, Abstract S4.18.
Della Donna L, Lagadec C, Vlashi E, Evers P, Dekmezian C, Behjat J, Pajonk F. Cancer stem cells – Lessons learned from needle in the haystack. Radiation Research Society Annual Meeting – Maui, September 2010, Abstract S302.
Della Donna L, Lagadec C, Vlashi E, Dekmezian C, Whitelegge J, Souda P, Pajonk F. The Activity of the 26S Proteasome is Modulated during the Different Phases of the Cell Cycle. 1st PPDUP (Proteomics of Protein Degradation & Ubiquitin Pathways) Conference, June 6th-8th, 2010, Vancouver, British Columbia, Canada.
Vlashi E, Lagadec C, Della Donna L, Meng Y, Dekmezian C, Pajonk F. Glioma stem cells perform oxidative phosphorylation, while the rest of glioma cells perform aerobic glycolysis. 101st Annual Meeting of American Association of Cancer Research, April 2010, Washington DC (abstract # 4697) (AACR-Bristol-Myers Squibb Oncology Scholar-in-Training Award)
Lagadec C, Vlashi E, Della Donna L, Meng Y, Dekmezian C, Kim K, Pajonk F. Survival and self-renewing capacity of breast cancer initiating cells during fractionated radiation treatment. 101st Annual Meeting of American Association of Cancer Research, April 2010, Washington DC (abstract # 4287) (AACR-Susan G. Komen for the Cure Scholar-in-Training Award)
Della Donna L, Lagadec C. Vlashi E, Meng Y, Dekmezian C, Souda P, Whitelegge J, Pajonk F. The activity of the 26S proteasome is modulated during the different phases of the cell cycle. 101st Annual Meeting of American Association of Cancer Research, April 2010, Washington DC (abstract #1813) (Merck Scholar-in-Training Award)
Lagadec C, Vlashi E, Della Donna L, Pajonk F. The response of breast cancer initiating cells to fractionated radiation. San Antonio Breast Cancer Symposium, December 2009, San Antonio, TX (abstract # 1153)
Vlashi E, Mattes M, Della Donna L, Lagadec C, McBride WH, Pajonk F. Effects of the proteasome inhibitor NPI-0052 in the radiation treatment of glioblastoma multiforme. Pathobiology of Cancer Workshop, July 2009, Snowmass, CO (abstract # B30)
Vlashi E, Lagadec C, Della Donna L, Mattes M, Nikolay P, McBride WH, Pajonk F, Characterization of radiation and chemotherapy resistance of glioma stem cells via a novel cancer stem cell marker. 100th Annual Meeting of American Association of Cancer Research, April 2009, Denver, CO (abstract # 1081)
Lagadec C, Vlashi E, Della Donna L, Mattes M, Nikolay P, McBride WH, Pajonk F. Low proteasome activity as a means to track and target breast cancer stem cells in-vivo. 100th Annual Meeting of American Association of Cancer Research, April 2009 Denver, CO (abstract # 4793)
Della Donna L, Vlashi E, Lagadec C, Whitelegge J, Souda P, Nikolay N, Mattes M, McBride WH, Pajonk F. Quantitative proteomic analysis of radiation induced posttranslational modifications of the 26S proteasome. 100th Annual Meeting of American Association of Cancer Research, April 2009, Denver, CO (abstract # 3552)
Della Donna L, Vlashi E, Lagadec C, Mattes M, Nikolay N, Schaue D, McBride WH, Pajonk F. Immunogenicity of prostate cancer stem cells. 100th Annual Meeting of American Association of Cancer Research, April 2009, Denver, CO (abstract # 4180)
Zumsteg Z, McBride WH, Cacalano N, Iwamoto K, Vlashi E, Pajonk F, Kim K. High throughput screening of small molecule libraries to identify novel 26S proteasome inhibitors. 100th Annual Meeting of American Association of Cancer Research, April 2009, Denver, CO
Lagadec C, Vlashi E, Della Donna L, McBride WH, Pajonk F. Treatment responses of breast cancer stem cells. San Antonio Breast Cancer Symposium, December 2008, San Antonio, TX (abstract # 5505).
Varghese B, Vlashi E, Low PS. Folate receptor saturation, recycling, and release kinetics in activated macrophages. ASH Annual Meeting Abstracts, December 2008 112: 4655
Vlashi E, Kim K, Lagadec C, Della Donna L, McDonald JT, McBride WH, Pajonk F. Low proteasome activity of glioma stem cells can be exploited for characterization of radiation and chemotherapy resistance. Radiation Research Society Annual Meeting, September 2008, Boston, MA (abstract # PS3576).
Lagadec C, Vlashi E, Della Donna L, Kim K, McDonald JT, McBride WH, Pajonk F. Proteomic exploration of the radiation-resistant phenotype of CSCs/CICs in breast cancer. Radiation Research Society Annual Meeting, September 2008, Boston, MA (abstract # PS3594)
Della Donna L, Lagadec C, Vlashi E, Kim K, McDonald JT, Whitelegge J, McBride WH, Pajonk F. Radiation-induced posttranslational modification and expression of proteasome subunits. Radiation Research Society Annual Meeting, September 2008, Boston, MA (abstract # PS3581)
McDonald JT, Kim K, Norris A, Vlashi E, Lagadec C, Della Donna L, McBride WH. Nrf2 expression but not activation mediates radiation resistance. Radiation Research Society Annual Meeting, September 2008, Boston, MA (abstract # PS3548)
Kim K, Norris A, McDonald JT, Damoiseaux R, Vlashi E, Lagadec C, Della Donna L, Micewicz E, Iwamoto K, McBride WH. High throughput screening of small molecule libraries to identify radioprotectors. Radiation Research Society Annual Meeting, September 2008, Boston, MA (abstract # PS3508)
Vlashi E, Kim K, Lagadec C, Della Donna L, McDonald JT, McBride WH, Pajonk F. Prospective identification, tracking, and targeting of cancer-initiating cells in breast cancer and glioma via low proteasome activity. 99th Annual Meeting of American Association of Cancer Research, April 2008, San Diego, CA (abstract # A5)
Vlashi E, Kim K, Della Donna L, McDonald JT, Lagadec C, McBride WH, Pajonk F. Proteasome activity as a means to identify, track, and target cancer-initiating cells. The Role of Cancer Stem Cells in the Identification and Propagation of Tumorigenesis (AACR Special Conference), February 2008, Los Angeles, CA (abstract # A5)
Low PS, He W, Vlashi E, Cheng JX, Kennedy M, Optical imaging of cancer cells in vivo with folate receptor-targeted fluorescent dyes. Proceedings of Microscopy and Microanalysis, Vol. 13, Supplement 2, 2007
Yang J*, Vlashi E*, Chen H, Vlahov I, Sturgis J, Robinson P, Cheng JX, Low PS. Real time imaging of tumor delivery, endocytosis and intracellular drug release of folate-targeted agents by FR+ solid tumors. 97th Annual Meeting of American Association of Cancer Research, April 2006, Washington DC, (*Both authors contributed equally), (abstract # 982)
Yang J*, Vlashi E*, Chen H, Vlahov I, Sturgis J, Robinson J, Cheng JX, Low PS. Real time imaging of accumulation of folate-targeted conjugates into solid tumor tissue and their disulfide-reduction mediated controlled release inside FR+ cancer cells. Purdue University Cancer Center Annual Scientific Retreat, September 2005, West Lafayette, IN (*Both authors contributed equally), (abstract # 22)
Vlashi E, Henne WA, Doorneweerd DD, Hilgenbrink AR, Low PS. Folate targeted chemotherapeutics and their size dependent penetration into solid tumor mass. 229th American Chemical Society National Meeting, Spring National Meeting, March 2005, San Diego, CA (abstract # MEDI 492)
Henne WA, Vlashi E, Doorneweerd DD, Hilgenbrink AR, Low PS. Folate targeted chemotherapeutics and their size dependent penetration into solid tumor mass.” American Chemical Society 36th Annual Great Lakes Regional Meeting, October 2004, Peoria, IL (abstract # 368)
Me njerëz të tillë duhet të krenohemi të gjithë ne.Për ngjarje të tilla duhet të shkruajnë apo të flasin mediat tona se sa nuk pushojnë të tregojnë se me kë u martua ky e çfarë tha e veshi ai.Mendoj kemi nevojë të pasurohemi shpirtërisht e intelektualisht .Shpresoj të ndikojë pak suksesi i shqiptarëve në botë për të na pakësuar maninë e të sharit e të përbuzurit të vetvetes.
Bravo shqiperia qe ka talente neper bot qe vete shteti shaiptar nuk idin, se merren me llafe pa bereqet thone kyej nga shqiperia,nuk interesohen as gazetaret per keto talente qe ti tregojn shqiptareve kto jemi ne neper bot,
Urime prof. Erina Vlashi!
Urime prof. Erina! Suksese te metejshme.
Te lumte moj vajze per te tilla lajme kemi nevoje suksese te metejshme qofsh e lumtur.